MS drug prevented fatal heart condition in lab study

Monday, January 30, 2012

A drug used to treat multiple sclerosis may also be effective at preventing and reversing the leading cause of heart attack, a new study has found.

Scientists found that Gilenya, a drug recently approved in the US for treating MS, was effective at reversing the symptoms of ventricular hypertrophy in mice.

Ventricular hypertrophy is a fatal cardiac disorder that can result in an abnormal heart rhythm (arrhythmia) and cardiac arrest. It is caused by sustained pressure on the heart due to stresses or diseases, such as hypertension (high blood pressure), valvular heart disease or myocardial infarction (heart attack), and is the leading cause of sudden cardiac death worldwide.

Researchers from The University of Manchester and the University of Illinois at Chicago have discovered that enhancing the activity of an enzyme molecule called Pak1 that is found naturally in our bodies using Gilenya produced remarkable results in mice with ventricular hypertrophy.

Study co-author Dr Xin Wang, a Lecturer in Molecular Cardiology in Manchester's Faculty of Life Sciences, said: "Cardiac hypertrophy is the pathological state to respond to sustained stresses on the heart resulting in increases in ventricular wall thickness and muscle mass of the heart. The condition is often associated with fatal complications, such as, heart failure and rhythm disorders, such as ventricular arrhythmias, leading to millions of deaths worldwide each year.

"Our research had previously identified the effect of Pak1 in preventing tissue damage caused by reduced blood flow to the heart, known as cardiac ischemic injury. This latest study used mice with a genetic modification of the Pak1 gene to show how the enzyme, when stimulated by Gilenya, prevented and even reversed the symptoms of ventricular hypertrophy."

The research, led in Manchester by Dr Ming Lei, Dr Xin Wang and Dr Elizabeth Cartwright, and in Chicago by Professor John Solaro and Dr Yunbo Ke, is published in the leading cardiovascular journal, Circulation.

Dr Lei, who is based in Manchester's Faculty of Medical and Human Sciences, added: "In recent years, escalating costs, risks, and uncertainty associated with drug development for treating cardiovascular diseases have posed daunting challenges to the pharmaceutical industry. Our discovery opens up fresh avenues for developing a new class of drug for treating several fatal heart conditions. The novel effect of this existing drug means that we have the potential to accelerate the availability of a new therapy for patients with these heart conditions."

###

'Pak1 as a Novel Therapeutic Target for Antihypertrophic Treatment in the Heart,' published in Circulation, (doi: 10.1161/CIRCULATIONAHA.111.048785)

University of Manchester: http://www.manchester.ac.uk

Thanks to University of Manchester for this article.

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Source: http://www.labspaces.net/117177/MS_drug_prevented_fatal_heart_condition_in_lab_study

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The Obama Campaign Is Now Using Mobile Payments Device Square For Fundraising

The latest technology to be adopted by the Obama campaign?Square. The mobile payments device is now being used by the Obama for fundraising, says the company. Staff, fundraisers and others are being equipped with the card reading devices, says Square, enabling the campaign to take donations on the go via Android devices, iPhones or iPads. "Whether you're a Republican or a Democrat, running for president or local assembly, Square makes it easier than ever for candidates, organizations and volunteers to fundraise for their cause," said a spokesperson for Square.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Df7cy5kc0cU/

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NKorea's young leader gets rock star treatment (AP)

SEOUL, South Korea ? North Korea's young new leader gets rock star treatment when he visits his troops ? just as his father did. But while the late Kim Jong Il mostly stayed aloof in dark shades, his son holds hands and hugs his soldiers.

Kim Jong Un seems to want to bond with his country's people.

The style harkens back to Kim Il Sung, his grandfather and revered founder of the country and ruling dynasty, and may reflect an attempt to turn a corner on the periods of hardship and famine under Kim Jong Il, analysts say. Kim Il Sung's image as a daring young general fighting Japanese colonial troops is powerfully engraved in the minds of North Koreans.

Cheers, applause and calls of "Hurrah!" greet Kim Jong Un as he examines the heating systems of soldiers' quarters, the pressure of their water faucets, the books stacked in their libraries ? even the taste of their food.

The North Korean state media reports and video footage of such "guidance visits" provide rare windows into the personalities of North Korea's leaders for outsiders and for the country's people alike. Few North Koreans, for instance, even knew what the elder Kim's voice sounded like, analysts say, despite his ruling for 17 years until his death Dec. 17.

In visits made so far by Kim Jong Un, believed to be in his late 20s, North Korea specialists have detected more warmth in his approach than the dour tours made in recent years by Kim Jong Il.

The younger Kim may be trying to emulate Kim Il Sung and move away from his father, who ruled during a famine in the mid- to late-1990s that killed hundreds of thousands, said Koh Yu-hwan, a North Korea professor at Seoul's Dongguk University. North Korea also has faced international condemnation and sanctions for its pursuit of nuclear weapons.

"He'll try to look comfortable among the masses. He'll try to form an intimacy with the people, perhaps more than his father did," Koh said.

Imitating Kim Il Sung is a "positive for Kim Jong Un, because memories of his father Kim Jong Il aren't very good among ordinary people," Koh said. "People fondly remember the days of Kim Il Sung."

Kim Il Sung often was pictured surrounded by children, and Kim Jong Un resurrected that image during a recent visit to the Mangyongdae Revolutionary School.

As children in military uniforms cheered and clapped, a documentary on state TV showed Kim embracing one child's face with his hands. During lunch, Kim patted students in encouragement and watched with a grin as two women ladled out soup for students; he poured a drop of sauce on his thumb so he could taste it.

His main emphasis, however, has been on military posts ? with a half dozen such visits since the New Year. They seek to show citizens that their new leader is firmly in command of the country's most important institution, its 1.2 million-strong military, and that he is loved and respected by young troops and elderly generals alike.

While Kim Jong Il had two decades to prepare for leadership, Kim Jong Un was only publicly unveiled as heir in 2010, and outside observers have raised doubts about Kim Jong Un's ability to lead a country locked in a nuclear standoff with its neighbors and Washington and with a history of attacking South Korea.

Animosity is still high between the Koreas. Six decades after the Korean War, the peninsula remains in a state of war because the 1950-53 conflict ended with an armistice, not a peace treaty. About 28,500 U.S. troops are stationed in South Korea to deter potential North Korean aggression.

Bloodshed spiked in 2010 when a South Korean warship exploded in disputed waters, killing 46. South Korea said the North torpedoed the warship; the North denied the allegation. North Korea also attacked a front-line South Korean island, killing four.

Kim Jong Un clearly has made attempts to appear active and engaged with his soldiers, and this "helps raise troops' morale and his profile," said Kim Yeon-su, a North Korea expert at Korea National Defense University. "North Korea is telling its people that Kim Jong Un is capable of doing all these military activities himself."

Kim Jong Un's first reported military visit after his father's death came on New Year's Day. He appeared at ease, laughing and clapping, pulling officers close to give them words of advice, inspecting bunks and testing water faucets.

State television has also played a documentary on Kim Jong Un meant to highlight his military experience, showing him in the cockpit of a tank, galloping by on horseback and poring over documents at night.

Despite his youth, Kim Jong Un often plays the part of a solicitous father during his meticulously documented military tours.

Wearing a dark overcoat similar to one Kim Il Sung favored as a young man or a light-colored parka like the one Kim Jong Il wore, he exchanges handshakes with cheering soldiers and takes group photos, often holding hands with the officers on either side of him.

He asks about the soldiers' warmth, their eating and sleeping arrangements, listens with apparent enjoyment to their musical performances, observes their "militant spirit of training," offers guidance to officers and takes "care of the soldiers' living as their real father would do," according to state media.

He even tastes their bean paste.

___

Associated Press writer Sam Kim contributed to this report from Seoul. Follow on Twitter: twitter.com/samkim_ap and twitter.com/APklug.

Source: http://us.rd.yahoo.com/dailynews/rss/nkorea/*http%3A//news.yahoo.com/s/ap/20120130/ap_on_re_as/as_nkorea_leader_s_visits

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What If I Ate Only One Type of Food? (LiveScience.com)

A British teenager collapsed and was rushed to the hospital this week after eating primarily chicken nuggets for the past 15 years. Stacey Irvine, 17, has reportedly survived on her nugget-heavy diet, occasionally supplemented by a bag of chips or piece of toast, since she was a toddler. Doctors have urgerd her to change her ways, but Irvine's case got us wondering: what would actually happen if you ate only one type of food for your entire life?

Depends on the poison you pick, but poison it most likely would be. According to Jo Ann Hattner, a nutrition consultant at Stanford University School of Medicine and former national spokesperson for the American Dietetic Association, choosing to eat only one fruit, vegetable or grain would lead to organ failure. Consuming only meat would eventually force your body to start munching on?your own muscles. And if you stuck solely to almost any one food (besides fruit), you would develop a serious case of scurvy.

"I wouldn't recommend this experiment," said Hattner, who also wrote "Gut Insight" (Hattner Nutrition, 2009), a book about digestive health.

No single vegetable or legume has all nine essential amino acids humans need to build the proteins that make up our muscles, Hattner said. That's why most human cultures, without knowing anything about food chemistry, have developed diets centered on complementary veggies that, together, provide all nine. At first, without all the right amino acids, your hair starts to lighten in color and your fingernails get soft. Much worse, "your lean body mass suffers. That doesn't just mean your muscles, but also your heart and your organs." Eventually, your heart shrinks so much you die; this happens, on occasion, with extreme cases of?anorexia nervosa.

Eating only one type of carbohydrate ? just bread or pasta, for example ? also causes organ failure, due to amino acid deficiency. On top of that, you'd get scurvy, a horrific disease brought on by lack of vitamin C, an essential component of many of the body's chemical reactions. Thanks to?highly unethical experiments?carried out on prison inmates in Britain and the United States in the 1940s, we know that scurvy hits after one to eight months of vitamin C deprivation (depending on the quantity one's body has stored to begin with). At first, you feel lethargic and your bones ache. Later, strange spots pop up all over your body and develop into suppurating wounds. You get jaundice, fever, tooth loss and, eventually, you die. [Why Don't Fad Diets Work?]

Life as a "meat purist" would also be a dead-end.

In addition to lacking vitamin C, most meats contain very few carbs ? the easy-to-access packets of energy your body constantly requires to perform even the smallest tasks. "Without carbohydrates, you're going to start to break down some of your muscle mass to get the energy," Hattner said. Again, "muscle" doesn't just mean your biceps. You'll be eating your own heart, too.

However, there is one food that has it all: the one that keeps babies alive. "The only food that provides all the nutrients that humans need is human milk," Hattner said. "Mother's milk is a complete food. We may add some solid foods to an infant's diet in the first year of life to provide more iron and other nutrients, but there is a little bit of everything in human milk."

Technically, adults could survive on?human milk, too, she said; the sticking point would be finding a woman who is willing to provide it (and enough of it). Lacking that option, the second-best choice would be mammalian milk, especially if it is fermented. "Yogurt, which is fermented milk, has a lot of bacteria that is good for the digestive tract," Hattner said.

These hypothetical scenarios aren't just whimsical speculation. In many parts of the world, people have no choice but to eat mostly one food: often, rice. Scientists are developing genetically modified rice that contains more vitamins and nutrients, especially vitamin A, in order to fight malnutrition.

Figuring out how to pack everything we need into one food is also useful for space travel, Hattner said. "The impetus of a lot of nutritional science is, 'How do we feed?people in space?' Scientists are trying to increase the nutritional concentration of food so you don't have a lot of bulk."

Follow Natalie Wolchover on Twitter @nattyover. Follow Life's Little Mysteries on Twitter @llmysteries, then join us on?Facebook.

Source: http://us.rd.yahoo.com/dailynews/rss/parenting/*http%3A//news.yahoo.com/s/livescience/20120128/sc_livescience/whatifiateonlyonetypeoffood

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Gingrich: Romney self-deportation plan a fantasy (AP)

DORAL, Fla. ? Republican presidential candidate Newt Gingrich on Wednesday ridiculed rival Mitt Romney's call for self-deportation of illegal immigrants as an "Obama-level fantasy" that would be inhumane to long-established families living in America. Romney, for his part, accused Gingrich of pandering to a Hispanic audience and said Gingrich himself had supported self-deportation in the past.

Discussing immigration in state where 13 percent of registered voters are Hispanic, the former House speaker criticized Romney's immigration policy during a forum with the Spanish-language television network Univision, saying the idea of self-deportation would never work. Romney snapped back at him later in the day at the same forum.

During a debate earlier this week, Romney said he favors self-deportation over policies that would require the federal government to round up millions of illegal immigrants and send them back to their home countries. Advocates of Romney's approach argue that illegal immigration can be curbed by denying public benefits to them, prompting them to leave the United States on their own.

"You have to live in a world of Swiss bank accounts and Cayman Island accounts and automatically $20 million income for no work to have some fantasy this far from reality," Gingrich said, alluding to details in Romney's income tax returns made public Tuesday. "For Romney to believe that somebody's grandmother is going to be so cut off that she is going to self-deport, I mean this is an Obama-level fantasy."

But Gingrich's campaign has spoken of the self-deportation policy he ridiculed Wednesday.

"I recognize that it's very tempting to come out to an audience like this and pander to the audience," Romney said, pointing out that Gingrich has previously made comments supporting the idea of self-deportation. "I think that was a mistake on his part."

In debates, Gingrich has defended a proposal to allow some illegal immigrants to stay in the U.S. if they've lived here for more than 25 years and have a local sponsor.

Romney's campaign directed reporters to past comments by Gingrich spokesman R.C. Hammond, who said that only a small percent of illegal immigrants would likely be allowed to stay in the U.S. under Gingrich's plan. Hammond went on to say that the vast majority of them would likely "self-deport."

Gingrich also ran into trouble over a radio ad calling Romney "anti-immigrant." Florida Sen. Marco Rubio called the ad "inaccurate" and "inflammatory." Romney's campaign also asked Gingrich in a letter to pull the ad. Gingrich's campaign had no immediate comment on whether it would comply with the request to pull the ad. The Miami Herald reported that the campaign planned to remove the ad based on Rubio's comments.

Romney called the anti-immigrant label an "epithet" and "inappropriate."

At the forum, Gingrich spoke instead about other elements of his immigration plan, including controlling the border and establishing a guest-worker program to better manage the influx of immigrants. Gingrich said he favors a path to citizenship for illegal immigrant children who serve in the military but not for simply completing college.

Romney defended his opposition to allowing the children of illegal immigrants to pay in-state tuition at American universities. He said there are inexpensive options that will allow them to go to college.

Gingrich told Univision he believes states should charge in-state tuition rates for students who were born in the U.S. to illegal immigrant parents, but that he favors charging out-of-state tuition for children who were brought to this country illegally.

Texas Gov. Rick Perry's support of a Texas policy to allow children of illegal immigrants to pay in-state tuition proved to be problematic with conservatives nationwide. Perry dropped out of the race last week.

Gingrich began the interview by speaking a few halting phrases of welcome in Spanish ? "Buenos Dias estudiantes" ? but begged off when moderator Jorge Ramos pressed him to go further. Romney did not speak any Spanish during his interview.

Romney was asked about family members he has living in Mexico. Romney's father, George Romney, was born in Mexico but moved back to the U.S. as a young child.

Ramos asked Romney if he had a claim to being Mexican American.

"I don't think people would think I was being honest with them if I said I was Mexican American but I'd appreciate it if you'd get that word out," Romney said, smiling.

Florida is home to many Hispanics of Puerto Rican or Cuban descent who don't view immigration as a priority but are more interested in the issue than the general public.

After the interview, Romney railed against Fidel Castro's Cuba in a speech before several hundred Cuban-American democracy activists. Romney has significant support from the Cuban-American political establishment in Miami.

"It is time for us to strive for freedom in Cuba, and I will do so as president," he said. "We must be prepared to support the voices for democracy in Cuba."

While the interview questions asked of both candidates were mostly about Hispanic concerns, Ramos asked Gingrich whether it was hypocritical for him to criticize then-President Bill Clinton and pursue his impeachment in the 1990s when Gingrich was being unfaithful to his second wife.

Gingrich snapped at the premise of the question and said it was Clinton's false testimony under oath that bothered him the most.

"The fact is I've been through two divorces. I've been deposed both times under oath. Both times I told the truth in the deposition," Gingrich said. "I have never lied under oath. I have never committed perjury."

Ramos asked Romney to declare his wealth, to which Romney replied that he's worth between $150 million and "200-and-some-odd million dollars."

Source: http://us.rd.yahoo.com/dailynews/rss/politics/*http%3A//news.yahoo.com/s/ap/20120125/ap_on_el_pr/us_campaign_hispanics

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France passes genocide law, faces Turkish reprisals (Reuters)

PARIS (Reuters) ? France approved on Monday a bill making it illegal to deny that the mass killing of Armenians by Ottoman Turks nearly a century ago was genocide, raising the prospect of a major diplomatic rift between two NATO allies.

Lawmakers in the upper house (Senate) voted 127 to 86 in favor of the draft law outlawing genocide denial after almost six hours of debate. The lower house had backed it in December, prompting Ankara to cancel all economic, political and military meetings with Paris and recall its ambassador for consultations.

The bill had been made more general so that it outlawed the denial of any genocide, partly in the hope of appeasing the Turks. It now goes to President Nicolas Sarkozy to be ratified.

"This day will be written in gold not only in the history of friendship between the Armenian and French peoples, but also in the annals of the history of the protection of human rights," said Armenia's Minister of Foreign Affairs, Edward Nalbandian.

Turkey's ambassador to France Tahsin Burcuoglu told reporters he was "saddened" by the vote and warned there would be permanent measures taken against France.

Armenia, backed by many historians and parliaments, says about 1.5 million Christian Armenians were killed in what is now eastern Turkey during World War One in a deliberate policy of genocide ordered by the Ottoman government.

The Ottoman empire was dissolved after the end of the war, but successive Turkish governments and the vast majority of Turks feel the charge of genocide is a direct insult to their nation. Ankara argues there was heavy loss of life on both sides during fighting in the area.

Earlier, Turkish Deputy Prime Minister Bulent Arinc told reporters at the Council of Europe in Strasbourg that Ankara would take new and permanent measures unless the bill was rejected and compared it to the Inquisition in the Middle Ages which was created by the Catholic Church to stamp out heresy.

"If the law is voted (through), it will hurt French and Turkish relations." Arinc said Turkey could take the matter to the European Court of Human Rights.

Turkey says the bill is a bid by Sarkozy to win the votes of 500,000 ethnic Armenians in France in the two-round presidential vote on April 22 and May 6.

It mandates a maximum 45,000-euro ($58,000) fine and a year in jail for offenders. France passed a law recognizing the killing of Armenians as genocide in 2001.

WAVING VOTING CARDS

About 200 Franco-Turks protested outside the Senate. They waved their French voting cards and banners with slogans including: "It's not up to politicians to invent history."

The Socialist Party, which has a majority in the upper house, and Sarkozy's UMP party, which put forward the bill, backed the legislation.

A non-binding Senate recommendation last week said the law would be unconstitutional and, after weeks of aggressive Turkish lobbying, there were suggestions the outcome would be closer.

Opponents in the Senate said the law would not encourage the Turks to recognize the Armenian genocide and would do nothing to help relations between the two nations.

"It is an unbearable law which calls into question historical research," said centre-left senator Jacques Mezard.

Sarkozy is expected to ratify the bill before parliament is suspended in February ahead of the presidential election.

It could still be rejected if some 60 lawmakers agree to appeal the decision at the country's highest court and that body considers the text unconstitutional. The Constitutional Council would have one month to make its decision.

Sarkozy wrote to Turkish Prime Minister Tayyip Erdogan last week saying the bill did not single out any country and that Paris was aware of the "suffering endured by the Turkish people" during the final years of the Ottoman empire.

French foreign ministry spokesman Bernard Valero called on Turkey not to overreact and said Paris considered Ankara a "very important ally."

Engin Solakoglu, first secretary at the Turkish embassy in Paris, said: "France can't continue to say that Turkey is an important ally when it votes laws against it."

European Union candidate Turkey could not impose economic sanctions on France, given its World Trade Organisation membership and customs union accord with Europe.

But the row could cost France state-to-state contracts and would create diplomatic tension as Turkey takes an increasingly influential role in the Middle East.

(Additional reporting by Lucien Libert in Paris, Gilbert Reilhac in Strasbourg and Daren Butler in Istanbul; editing by Robert Woodward)

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/nm/20120123/wl_nm/us_france_turkey_genocide

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"The Artist" wins over producers at Guild Awards (omg!)

LOS ANGELES (Reuters) - "The Artist" continued its love affair with American cinema after winning best-produced film on Saturday at the Producers Guild Awards (PGA), boosting its chances for an Oscar nod ahead of the Academy Award nominations next week.

The silent black-and-white French comedy, starring Jean Dujardin and Berenice Bejo, is a homage to the pre-talkie era of Hollywood in the 1920s and 1930s and tells the story of a fading silent movie star as sound began entering the world of cinema.

"When Michel Hazanavicius and I dreamed of making "The Artist," we knew we were dreaming of writing a love letter to American cinema. We never knew in return we would get a taste of the American dream," Thomas Langmann, the film's producer, said in his acceptance speech in Beverly Hills.

The film has been sweeping awards ceremonies in the run up to the Oscars, winning best picture at the Critics Choice and Golden Globes earlier this month.

It was up against nine other films in contention for best-produced film on Saturday, including female-led comedy "Bridesmaids," civil rights drama "The Help," and Steven Spielberg's epic tale "War Horse."

"The Adventures of Tintin," produced by Spielberg, picked up best-produced animated film.

The Producers Guild awards are significant in the race to the Academy Awards on February 26, as many of the 5,000-plus members of the PGA, are members of the Academy of Motion Picture Arts and Sciences, who vote for the Oscars.

For the last four years, the producers' best-produced film picks have gone on to win the best picture Oscar, with "No Country For Old Men" in 2008, "Slumdog Millionaire" in 2009, "The Hurt Locker" in 2010 and "The King's Speech" in 2011.

Other PGA award winners on Saturday included "Beats, Rhymes & Life: The Travels of a Tribe Called Quest" for best-produced documentary, which explores the journey of influential hip-hop group A Tribe Called Quest.

Angelina Jolie received the Stanley Kramer award for "In the Land of Blood and Honey," which she wrote, directed and produced, an accolade reserved for contributions that highlight provocative social issues.

The Oscar-winning actress delivered a sober acceptance speech, noting that when war-film "Schindler's List" won a PGA in 1994 during the Bosnian war, "the world turned a blind eye" to the atrocities happening in Eastern Europe at the time.

Spielberg was awarded the coveted David O'Selznick achievement award and comic-book legend Stan Lee received the Vanguard award, presented by "Spiderman" actor Tobey Maguire. Both received standing ovations as they took the stage.

ABC's "Modern Family" was named best-produced television comedy for the second year running, while HBO's "Boardwalk Empire" was named best-produced TV drama. PBS' British period drama "Downtown Abbey" was named best-produced long-form television series.

(Reporting by Piya Sinha-Roy; Editing by Paul Simao)

Source: http://us.rd.yahoo.com/dailynews/rss/entertainment/*http%3A//us.rd.yahoo.com/dailynews/external/omg_rss/rss_omg_en/news_artist_wins_over_producers_guild_awards082419556/44261265/*http%3A//omg.yahoo.com/news/artist-wins-over-producers-guild-awards-082419556.html

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